This meatloaf sandwich is a comforting classic! Layers of juicy meatloaf are tucked between two slices of soft bread, making it the perfect lunch or dinner treat.
You can’t go wrong with this tasty sandwich, especially with some ketchup spread on top! It’s a great way to enjoy leftovers, and let’s face it, who doesn’t love a good meatloaf? 😋
Key Ingredients & Substitutions
Ground Beef: While 80/20 ground beef gives great flavor and moisture, you can swap it with ground turkey or chicken for a leaner option. Just keep in mind the flavor might be slightly milder.
Breadcrumbs: I like using plain breadcrumbs for this recipe, but you can substitute with crushed crackers, panko, or even gluten-free breadcrumbs. Each will give a unique texture to your meatloaf.
Parmesan Cheese: This adds a delicious depth of taste. If you’re out, you can use shredded cheddar, pecorino, or nutritional yeast for a dairy-free option!
Cheese: Provolone is my go-to for its meltiness, but feel free to use cheddar, Swiss, or any cheese that melts well. Vegan cheese can also work if you prefer a plant-based version.
Bread: I love thick-cut sourdough for its crunch and flavor. However, any sturdy bread like whole wheat or brioche will do. Gluten-free bread works for a gluten-free option!
How Do I Ensure My Meatloaf Stays Moist?
Keeping your meatloaf juicy is key for a delicious sandwich! The blend of beef, breadcrumbs, eggs, and milk is designed to lock in moisture. Here are some tips:
- Avoid Overmixing: Mix just enough to combine ingredients. Overmixing can lead to a dense loaf.
- Use a Meat Thermometer: Cooked meatloaf should reach 160°F (71°C). Don’t overbake to avoid dryness.
- Baste with Sauce: Brushing ketchup or sauce on top for the last few minutes keeps it moist and adds flavor.
- Rest Before Slicing: Let it cool for about 10 minutes after baking. This helps juices redistribute, making for a great sandwich!
By following these tips, you’ll have a flavorful and juicy meatloaf for your sandwiches! Enjoy your tasty creation! 🍔

Meatloaf Sandwich
Ingredients You’ll Need:
- For the Meatloaf:
- 1 pound ground beef
- 1/2 cup breadcrumbs
- 1/4 cup grated Parmesan cheese
- 1/4 cup finely chopped onion
- 1/4 cup milk
- 1 large egg
- 2 cloves garlic, minced
- 1 teaspoon Worcestershire sauce
- 1 teaspoon dried Italian seasoning or oregano
- Salt and black pepper, to taste
 
- For the Sandwich:
- 4 slices sandwich bread (thick cut, white or sourdough)
- 4 slices provolone or mozzarella cheese
- 2 tablespoons butter, softened
- Optional: 1/4 cup tomato sauce or ketchup for topping the meatloaf inside the sandwich
 
How Much Time Will You Need?
This meatloaf sandwich will take about 10 minutes to prep, 45-55 minutes to bake the meatloaf, and about 10 minutes to cook the sandwich. In total, you’re looking at around 1 hour and 15 minutes until you’re enjoying this delicious comfort food!
Step-by-Step Instructions:
1. Prepare the Meatloaf:
Start by preheating your oven to 350°F (175°C). Lightly grease a loaf pan or line it with parchment paper for easy removal. In a large bowl, add the ground beef, breadcrumbs, grated Parmesan, chopped onion, milk, egg, minced garlic, Worcestershire sauce, Italian seasoning, salt, and black pepper. Mix gently until everything is combined, but be careful not to overwork the meat.
2. Bake the Meatloaf:
Shape the meat mixture into a loaf and transfer it to your prepared loaf pan. Bake for about 45-55 minutes until the meatloaf is fully cooked through and the juices run clear. Optional: during the last 10-15 minutes, you can spread some tomato sauce or ketchup on top for extra flavor.
3. Slice and Prepare the Sandwich:
Once the meatloaf is done, let it cool for a few minutes. Then, slice it into thick pieces that are perfect for sandwiches. Butter one side of each slice of bread. Heat a skillet or griddle over medium heat.
4. Build the Sandwich:
To assemble, place a slice of meatloaf on the unbuttered side of one slice of bread. Add a slice of cheese, then top with another slice of bread, butter side out. This will ensure a delicious golden brown crust when cooked!
5. Cook the Sandwich:
Put the assembled sandwich in the heated skillet. Cook for about 3-4 minutes on each side, or until the bread is golden brown and crispy, and the cheese is nicely melted. Use a spatula to press down gently to seal the sandwich.
6. Enjoy!
Once cooked, remove the sandwich from the skillet, slice it in half, and serve warm. This meatloaf sandwich, with its crispy, buttery bread and savory filling, is sure to be a hit!
Perfect comfort food for lunch or dinner—enjoy!
Can I Use Leftover Meatloaf for This Sandwich?
Absolutely! Leftover meatloaf is perfect for sandwiches. Just slice the meatloaf and follow the remaining steps to assemble your sandwich. It’s an excellent way to repurpose a delicious meal!
What If I Don’t Have Breadcrumbs?
No worries! If you’re out of breadcrumbs, you can use crushed crackers, panko, or even oats as a substitute. Each will give a slightly different texture and flavor but will work just fine in the meatloaf!
Can I Make This Sandwich Ahead of Time?
Yes, you can prepare the meatloaf ahead of time and store it in the fridge for up to three days. When you’re ready to enjoy your sandwich, simply slice and assemble, then cook it fresh for the best taste!
How Should I Store Leftovers?
If you have leftovers, store them in an airtight container in the fridge for up to 3 days. To reheat, simply warm slices in the microwave or on a skillet until heated through and the cheese is melted again!
